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P Wave Dispersion in Patients with Generalised Anxiety Disorder
Muhammed Fatih Tabara1, Mustafa Cakar2, Sema Baykara3, Mehmet Gurkan Gurok1, Sevda Korkmaz1, Osman Mermi1, Mustafa Ferzeyn Yavuzkir4, Murad Atmaca11Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkiye2Clinic of Psychiatry, Elazig Mental Health and Diseases Hospital, Elazig, Turkiye
3Department of Psychiatry, Erenkoy Mental and Nervous Diseases Hospital, Istanbul, Turkiye
4Department of Cardiology, Firat University, School of Medicine, Elazig, Turkiye
INTRODUCTION: Generalised anxiety disorder (GAD) is primarily characterized by persistent anxiety and worry, factors which are potentially associated with alterations in P-wave parameters. This study aimed to investigate P-wave dispersion in patients with GAD to determine if these atrial electrophysiological changes are present in this population.
METHODS: P-wave dispersion, along with Pmax and Pmin values, was assessed via electrocardiography (ECG) in twenty patients with GAD and twenty age- and sex-matched healthy controls.
RESULTS: Statistical analysis revealed that Pmax and Pmin values were significantly elevated in patients with GAD compared to healthy controls. Notably, the primary outcome measure—mean P-wave dispersion—was significantly higher in the patient cohort (50.74 ± 6.10 ms) than in the control group (35.32 ± 3.79).
DISCUSSION AND CONCLUSION: In conclusion, patients with GAD exhibited significantly higher Pmax, Pmin, and P-wave dispersion values compared to healthy controls. These findings suggest that individuals with GAD may warrant closer clinical monitoring of their atrial electrophysiology.
Keywords: P wave dispersion, generalised anxiety, disorder, ECG
Manuscript Language: English