E-ISSN: 2587-0351 | ISSN: 1300-2694
Investigation of relationship between lumbar Modic changes and serum vitamin D concentrations [Van Med J]
Van Med J. 2024; 31(2): 142-146 | DOI: 10.5505/vmj.2024.46855

Investigation of relationship between lumbar Modic changes and serum vitamin D concentrations

Server Ilter1, Veysel Delen2, Murat Toprak1, Remziye Akçalı3
1Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Yüzüncü Yıl University, Van, Turkey
2Department Of Physical Medicine And Rehabilitation, Faculty Of Medicine, Harran University, Şanlıurfa, Türkiye
3Department Of Physical Medicine And Rehabilitation, Mehmet Akif Inan Research And Training Hospital, Şanlıurfa, Türkiye

INTRODUCTION: There is limited and inconsistent data on the relationship between vitamin D deficiency and Modic changes (MCs). Also, which type of MCs is associated with vitamin D is not clear. Vitamin D has anti-inflammatory effects, while type 1 MCs have inflammatory nature. Accordingly, patients with type 1 may have lower vitamin D levels than those with type 2 MCs. This study aimed to compare type 1 and type 2 MCs for serum vitamin D concentrations.
METHODS: Between May 2019 and July 2020, a total of 53 patients with type 1 or type 2 MCs were included in this study. Patients’ demographics were recorded, and back pain severity was assessed by using visual analog scale. Serum levels of vitamin D were measured as total 25 hydroxy vitamin D. Accordingly, serum levels of vitamin D (µg/L) are graded as deficient (<20), insufficient (20-30), and sufficient (30-80).
RESULTS: Type 1 MCs (n=26) and type 2 MCs (n=27) groups were similar in age (p=0.199), gender (p=0.372), BMI (p=0.418), work status (p=0.593), pain duration (p=0.947), vitamin D concentration (p=0.402), degree of vitamin D deficiency (p=0.773), and spinal levels (p=0.726). Type 1 MCs patients had more painful low back than type 2 MCs patients (p=0.016).
DISCUSSION AND CONCLUSION: Type 1 MCs are similar to type 2 MCs for serum vitamin D concentration. The more painful low back of type 1 MCs may be related to its inflammatory nature, but may not be associated with vitamin D insufficiency.

Keywords: Vitamin D, Modic changes, back pain, inflammation.

Corresponding Author: Server Ilter, Türkiye
Manuscript Language: English
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