The Effects of Epinephrine, Norepinephrine and Dopamine on Hemogram and Coagulation Parameters
Yunus Emre Tunçdemir1, Nureddin Yüzkat2, Yasemin Bayram3, Yıldıray Başbuğan4, Kamil Cintan1, Ömer Türk11Department Of Anesthesiology and Reanimation, Van Training And Research Hospital, The Ministry Of Health, Van, Turkey2Department Of Anesthesiology and Reanimation, Faculty Of Medicine, Van Yuzuncu Yil University Van, Turkey
3Department Of Clinical Microbiology, Faculty Of Medicine, Van Yuzuncu Yil University Van, Turkey
4Faculty Of Veterinary Medicine, Van Yuzuncu Yil University, Van, Turkey
INTRODUCTION: Vasopressor agents stimulate endothelial cells and platelets via the sympathetic nervous system and affect the coagulation cascade through various mediators. This study aimed to investigate the effects of epinephrine, norepinephrine, and dopamine on hemogram and coagulation parameters.
METHODS: A total of 28 healthy Wistar albino rats weighing 250-300 grams were used in this study. The rats were randomly divided into four groups, with 7 in each group. 0.9 % serum physiologic (group C, n=7), epinephrine (group E, n=7), norepinephrine (group NE, n= 7), dopamine (group D, n=7) were intraperitoneally perfused to the rats under sedation. Blood samples were drawn from the rats 30 minutes after perfusion. Hemogram and coagulation parameters were compared between the groups.
RESULTS: Granulocyte values were lower in the dopamine group (p=0.014). Platelet cluster count was higher in the dopamine group (p=0.001). The highest hemoglobin and hematocrit values measured among the groups were observed in Group E, and its values were higher than those in the norepinephrine and control groups (p=0.047 and 0.030, respectively).
DISCUSSION AND CONCLUSION: It has been determined that vasopressor drugs affect hemogram values and platelet aggregation in different ways, but do not cause any changes in coagulation parameters.
Manuscript Language: English