Heterotopic Ovary Transplantation Containing Periovarian Adipose Tissue
Murat Serkant Ünal1, Hale Yetgin1, Cihan Kabukçu2, Aliye Uysal1, Anıl Duran1, Abdullah Coguplugil3, Nazlı Çil1, Gulcin Abban Mete11Department of Histology and Embryology,Pamukkale University, Denizli,Turkey2Department of Obstetrics and Gynecology,Pamukkale University, Denizli,Turkey
3Experımental Surgery Applıcatıon And Research Center,Pamukkale University, Denizli,Turkey
INTRODUCTION: Hypoxia and ischemia occurring after ovarian transplantation lead to significant follicular losses.The aim of this study was to prevent follicular losses during ovarian tissue transplantation through periovarian adipose tissue, without the need for any scaffold, bioengineering applications, or vascular anastomosis.
METHODS: In our study, fresh ovaries (maintaining their structural integrity) were transplanted into the dorsal muscles of the rat along with periovarian adipose tissue.
RESULTS: Our findings indicate that paracrine factors secreted by fibroblasts in the tunica albuginea and fibrous sheath, along with adipocytes and mesenchymal stem cells in periovarian adipose tissue, effectively prevent ischemia in ovarian tissue and accelerate angiogenesis.
DISCUSSION AND CONCLUSION: Based on our findings, periovarian adipose tissue effectively prevents ischemia in ovarian tissue and plays a crucial role in preserving the ovarian follicle reserve, without the need for scaffolds, bioengineering applications, or vascular anastomosis
Manuscript Language: English